More information. Denosumab Denosumab (Subcutaneous Route) Description injection They can give you tips on how to deal with any side effects that may be bothersome. Denosumab is also used to treat giant cell tumor of the bone that cannot be removed by surgery. Do not use Prolia if you have low calcium levels in the blood (hypocalcaemia). Nonprofit organization focused on promoting the use of vaccines by distributing information about vaccines and the diseases they prevent. Become a student member today for free and be part of the RACGP community, RACGP offer courses and events to further develop the knowledge you need to develop your GP career, Discover a world of educational opportunities to support your lifelong learning, The RACGP is working hard on transitioning to college-led general practice training, Become a provider with the CPD Program and be recognised for the quality education and training you offer GPs, The Abuse and violence: working with our patients in general practice provides the best-available current evidence for GPs. To learn how to talk to your patient and calm them down before giving an injection, read more from our Nurse co-author! Serious side effects of Prolia. You should always consult your doctor or another healthcare professional before taking any medication. It may harm them. A once-a-year injection is also far easier to schedule and stick to compared to having to remember a daily pill. Use this tracker to help. prolia Pain, including joint pain, is a possible side effect of Prolia. View denosumab information, including dose, uses, side-effects, renal impairment By subcutaneous injection. And if you've already had a fracture in your spine, your risk of having more than one broken bone in your spine is also increased. Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. Denosumab Prolia (Denosumab) Your doctor will test your blood calcium levels, which must be regular in order to start treatment. Denosumab injection (Prolia) is usually given once every 6 months. Breast Cancer and Back Pain {{configCtrl2.info.metaDescription}} Sign up today to receive the latest news and updates from UpToDate. She received her Master of Science in Nursing (MSN) from the University of Tennessee in 2006. We use cookies to make wikiHow great. How to Give a Prolia Injection How can I get proof of my COVID-19 vaccinations? Tell your doctor if you are pregnant, are planning a pregnancy, think you are pregnant, or are breastfeeding. Its not common, but your doctor may give you the option to self-inject Prolia at home. Denosumab may be an option if a woman cannot tolerate bisphosphonates. Prolia is given as a subcutaneous injection by your doctor, pharmacist, or another healthcare professional, in most cases.. View all bones muscles and joints. Unrelated to bisphosphonates, denosumab might be used in people who can't take a bisphosphonate, such as some people with reduced kidney function. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. To learn how to talk to your patient and calm them down before giving an injection, read more from our Nurse co-author! Serious side effects of Prolia. Review/update the Thanks to all authors for creating a page that has been read 570,971 times. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. You might have other treatments such as steroids to reduce the pressure on the spinal cord, as it can also help to control any pain. It is usually injected by a doctor or nurse in a medical office or clinic. To provide you with the most relevant and helpful information, and understand which Do not take XGEVA if you take Prolia. (2012). Yes No. Over 24 months, the incidence of new or worsening vertebral fracture was 3.6% in the denosumab group versus 10.3% in the placebo group, a risk reduction of 65.7% (P = 0.0001). Mayo Clinic Cellulitis has been more frequently reported with denosumab compared with placebo, although the incidence remains low (less than 0.2 events per 100 subject-years for long-term denosumab). It is given when other medicines cannot be used or after other medicines did not work well. Denosumab slows down the natural rate your bones are broken down. This will help you to get the most benefit from XGEVA. Denosumab Injection 431 0 obj <>/Filter/FlateDecode/ID[<30A52E187DB7394E9E664D34C4FC2508>]/Index[410 45]/Info 409 0 R/Length 94/Prev 38752/Root 411 0 R/Size 455/Type/XRef/W[1 2 1]>>stream It can be helpful to pull up the skin around the injection site with your non-dominant hand (as your dominant hand will be doing the injection) prior to injecting. Tell your doctor right away if you become pregnant. Prolia is safe to use for as long as your doctor recommends. As a consequence, osteoclast formation, function and survival is disrupted, resulting in decreased bone resorption and increased mass and strength of both cortical and trabecular bone. Learn how the drugs uses, effectiveness, and side effects, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Prolia comes in one strength: 60 milligrams (mg) per 1 milliliter (mL) of liquid solution. XGEVA is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors. Talk to your doctor in advance about setting up an appointment for once every 4 weeks. Methods. The subjects were randomized to either 60 mg of denosumab by subcutaneous injection every 6 months or placebo, together with calcium and vitamin D supplements. The best places to inject are the top of your thighs and the abdomen. Keep Prolia and all medicines out of reach of children. Sterilize the top of the vial with an alcohol swab. Join LiveJournal Denosumab injection comes as a solution (liquid) to be injected subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area. The recommended injection sites for Prolia include: the upper arm OR the upper thigh OR the abdomen. It works by blocking a protein and suppressing the cells that break down bone. The medication is designed to be injected into a muscle and not into the bloodstream, so if you see any red color when you pull back you will need to remove the needle and dispose of it. Denosumab injection is also used to treat bone loss in men with prostate cancer and women with breast cancer who are receiving cancer treatment. What is XGEVA (denosumab)? Note: This document contains side effect information about denosumab. The content of this article is not intended to be a substitute for professional medical advice, examination, diagnosis, or treatment. denosumab These are not all the possible side effects of XGEVA. If you take really high doses of vitamin A or D, you may absorb too much calcium. qSS9;a: 6h. Your doctor can give you drugs to help control some side effects. Follow your doctors instructions about how long you should continue to receive Prolia injections. Denosumab has been registered for the treatment of osteoporosis in Australia since 2010, and is subsidised by the Pharmaceutical Benefits Scheme for men and women over the age of 70 years with a T-score 2.5 or less, and for men and women with a minimal trauma fracture. Your doctor or nurse will give you this injection. For example, in the studies, people taking Prolia for up to 8 years didn't have significant side effects compared with people taking a placebo. low calcium levels (especially if you have kidney problems). The Food and Drug Administration (FDA) has approved it to: Prolia is typically used with calcium and vitamin D supplements. Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported. Denosumab can be used even in some cases of reduced kidney function. Patients with a type of cancer called Giant Cell Tumor of Bone and patients with bones that are not fully matured are at a greater risk to develop high blood calcium levels after they stop taking XGEVA, You should not become pregnant while taking XGEVA, Have symptoms of low blood calcium such as muscle stiffness or cramps, Have symptoms of severe jaw bone problems such as pain or numbness, Have ongoing pain or slow healing after dental surgery, Have symptoms of high blood calcium such as nausea, vomiting, headache, and decreased alertness, Are pregnant, plan to become pregnant, suspect you are pregnant, or breastfeeding, Tell your doctor about all medications you are taking. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Are there alternatives to Reclast and Prolia for osteoporosis? Women on teriparatide or abaloparatide need to give themselves a daily injection. Denosumab: updated recommendations Mayo Clinic Women should use highly effective birth control when taking XGEVA. Yes, Prolia (denosumab) does increase bone density. It is used to treat secondary bone cancer. If the person recently received an injection in one area, administer the shot in a different spot on their body. It is often used when other treatments have failed. Denosumab. If the drug works well for you and youre not having bothersome side effects, youll likely use the drug over a long period. (An active ingredient is what makes a drug work.) Hypocalcaemia following denosumab administration is a significant risk in patients with severe renal impairment (chronic kidney disease stage 4 or 5) or in patients receiving dialysis. If you have missed a dose, it is important to talk to your doctor about getting back on track with XGEVA. Now I have to make appointment with urology. Last medically reviewed on March 14, 2022. The active drug in Prolia is denosumab, which is a biologic medication. If your doctor says that this is safe for you, youll be shown how to inject Prolia. A healthcare provider will give you this injection. It is used to prevent bone problems in patients with multiple myeloma and bone metastases (cancer that has spread) from tumors. This drug is often used to treat people with cancer-caused hypercalcemia who don't respond well to bisphosphonates. You might have other treatments such as steroids to reduce the pressure on the spinal cord, as it can also help to control any pain. You only need to do this for dorsogluteal muscles since youre close to the gluteal artery. Your doctor will check if you are pregnant before starting XGEVA. Denosumab is a targeted therapy drug. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. (A biologic is made from parts of living organisms.) There are pamphlets and videos that can teach you how to give yourself an injection under the skin. Denosumab injection comes as a solution (liquid) to be injected subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area. Injection Your doctor can give you drugs to help control some side effects. Denosumab (Prolia) is a monoclonal antibody given as a twice-yearly injection. You should be using somewhere between a 22 and a 30 gauge needle (this will largely be determined by the thickness of the medication your doctor will tell you which gauge to use). Took medicine, UTI gone but the chill stay. Denosumab if you are allergic to denosumab or any of the other ingredients of this medicine (listed in section 6).. What is the alternative to taking Prolia? Diagnosis Like the bisphosphonates, denosumab also blocks osteoclasts, but it does so in a different way. Prolia Side Effects Sign Up If you would like more information, talk with your doctor. How often do I need to have this treatment? *Serious bone problems are defined as broken bones (fractures), the need for surgery to bones, the need for radiation treatments to the bone, and spinal cord compression. XGEVA is a bone-targeting medicine used to prevent serious bone problems. Denosumab (Subcutaneous Route) Description unlocking this expert answer. In clinical studies, osteonecrosis of the jaw (ONJ) was reported in some people taking XGEVA, which can be serious. Last Sept'20 took this Prolia injection. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Theyll help reschedule your missed dose for as soon as possible. Zometa (zoledronic acid) is an injection for hypercalcemia due to cancer, multiple myeloma, and bone metastases of tumors. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. And, older people are more likely to be affected by osteoporosis, which Prolia is used to treat. To help make sure that you dont miss a dose, try using a medication reminder. other information we have about you. Hypercalcemia of Malignancy . If the skin is stretched flat, that only use a. See the How Prolia is given section below to learn more. Where is Prolia injected? denosumab You dont need to pull the plunger back for any other IM injections. This can include setting an alarm or timer on your phone or downloading a reminder app. Denosumab Injection This content does not have an English version. The quicker the insertion, the less pain your patient will feel. Also, pulling back to check for blood. blood calcium must be treated before you receive XGEVA. If you do this, its important that you dont use more Prolia than your doctor prescribes. Insert the needle through the rubber top of the vial and press the plunger, pushing the air into the vial. Osteoporosis drugs: Which one is This article describes the typical dosage of Prolia provided by the drugs manufacturer. There are 21 references cited in this article, which can be found at the bottom of the page. Prolia (denosumab) is a prescription brand-name medication. The medicine can be injected into the skin of the thigh or abdomen. You may opt-out of email communications at any time by clicking on You are encouraged to report negative side effects of Risk of high calcium levels in patients with Giant Cell Tumor of Bone and in patients who are still growing, Increased risk of broken bones in the spine after discontinuing XGEVA. Stay up-to-date with the latest information and resources on the COVID-19 vaccine rollout. Note: This document contains side effect information about denosumab. {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/1\/17\/Give-an-Intramuscular-Injection-Step-7-Version-2.jpg\/v4-460px-Give-an-Intramuscular-Injection-Step-7-Version-2.jpg","bigUrl":"\/images\/thumb\/1\/17\/Give-an-Intramuscular-Injection-Step-7-Version-2.jpg\/aid1384620-v4-728px-Give-an-Intramuscular-Injection-Step-7-Version-2.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"