Our business dynamics in Sandoz, as you saw, in the quarter have really stabilized. The expected Innovative Medicines core margin increase will be driven by good top line momentum and continuation of productivity programs, including the recently announced new organizational structure. Our targets to be carbon neutral, plastic neutral and water sustainable are the central focus of our environmental sustainability strategy. I don't recall exactly, but I'll look into the point you raised around what we said previously on interim, certainly a very fair challenge. In 2020, our own operations (Scope 1 and Scope 2) represented 9% of our overall carbon footprint (Scope 1, Scope 2 and Scope 3). Learn more How we create value So moving to the next slide. So just first of all, just a quick follow-up to the first question I asked on NATALEE. But we want to have our focus be to build scale in those 5 priority TAs and again have the discipline always to chase anything else that might be around in other therapeutic areas. I wonder if you had any comments. Q. Times Internet Limited. Just on your Innovative Medicines, 40% plus margin target, I'm trying to square that with some of your peers. Thanks. Other than where indicated, environmental data for the current year are based on actuals for January-September and estimates for October-December (to be updated with actuals in H2 2022 in our annual Novartis Environmental Sustainability and Occupational Health and Safety Data Supplement). So there is plenty of space here for many agents. They'll do that through stepped-up rebating. food companies headquartered in georgia. Your next question comes from the line of Florent Cespedes from Societe Generale. We feel confident in our overall contracting position given the volumes we currently have with Cosentyx and the positions we have with the relevant formularies. In 2021, we launched Novartis Green Expectations from Suppliers, which requires suppliers to map out their emissions, water consumption and waste footprint baselines; understand water quality thoroughly; set targets; and report their progress. Yes. We're pursuing these three goals: 1 Build the road to carbon neutrality by 2030 and net zero by 2050 2 Limit our environmental footprint and adopt circular solutions 3 Improve environmental profile of our products Climate change is one, if not the greatest, challenge of our age It has an enormous impact on our lives and health. Thanks, Harry. The market trends show a recovery to pre-COVID levels for CDK4/6 TRx, but we continue to see a suppression in the NBRx part of the market. country participation. Copyright 2022 Surperformance. Q. Next question operator. Q. Q. I wanted to come back to Sandoz. Reorganizing so that we become much more agile, efficient, take out costs out of the system, improve our overall operating performance both on the top and bottom line generate differential growth. If we go to Slide 4. Novartis collaborates with others to help address some of the world's greatest health challenges. And in terms of the specifics on the Humira dynamics, et cetera, again, I think that's all built into the forecasted numbers that I gave you right there. So that's the broad strategy. More than 800 Novartis researchers across 24 laboratory sites in 11 countries took part in the certification process. Thank you for joining us today for Novartis' quarter 1 2022 results. But again, so far, we don't see or very limited impact of this. Novartis Financial Results - Q3 2022 Oct 25, 2022 Media Release Novartis announced the company's financial results for the third quarter of 2022. Sandoz ( A Novartis Company) Jun 2008 - Dec 20113 years 7 months. And I think in those segments of the market that have high utilization of buy-and-bill, there's less interest in using Kesimpta. Again, early days, particularly in the US, but I think the leading indicators point to the foundations being put in place to have this brand become a very significant brand for the company. (inaudible) depending on the rebates, we have to get a plus or minus low single-digit environment. But that's not the case yet with any of them. Unusually, across the industry, Novartis has built and is building a large cardiovascular presence. Q. But can you give us any sort of idea of that sort of significant year-on-year gross sorry, core operating income margin improvement? The rising prevalence of breast cancer will be a key driver fueling the breast cancer therapeutics market growth during the forecast period. Advancing our Play to Win Strategy in 2021. So we do see now moving towards the bottoming out of the US business as we look to get that region back to growth. Thank you, Vas. Thank you, Vas. It was flagged up on a call yesterday that traditionally Russia and Ukraine is disproportionately involved in MS studies. See Sustainalytics' high-quality public ESG risk ratings for over 10,000 companies. Sorry, one note I forgot to mention. And related to that, I see last week, you pushed back the time lines for your genome-edited stem cell therapy for sickle cell from late '23 to August '25. Facebook. Some important innovation milestones, I'll go through those in a bit more detail. And then we need to make a kind of sober evaluation as to is it a doable study in light of the waning rates of COVID around the world and then we can make an appropriate decision. The Board is planning to split the combined, Commitment to Diversity in Clinical Trials. So it's 35 on the slide, but we're up to 50, have ordered Leqvio. A. For further Scope 3 disclosures, please see our latest HSE supplement. Jeanette has 17 jobs listed on their profile. And so both the studies are moving forward. We aim to improve global health. You noted the weakness in new prescriptions, but even during the pandemic, Kisqali was, at worst, flat. Now in terms of impairments, we would have to see, but I don't expect actually impairments on it. It seems that you're doing a lot on a very short period of time. We certainly see the highest uptake in Kesimpta in segments of the market that are not highly penetrated by buy-and-bill. I wonder, firstly, Vas, if you could elaborate on the statement in the press release about lower demand for Kymriah. And I think in the intervening years, it's really just managing Kymriah to provide it to patients to really focus on that next-wave technology. Your next question comes from the line of Laura Sutcliffe with UBS. So we struck a partnership with Blackstone Life Sciences. Just a question on the phasing of the impact of inflation on the cost lines. So on the next slide, we present our results for the quarter. Distributed by Public, unedited and unaltered, on 03 February 2022 09:28:05 UTC. Next question operator. Perhaps one on JDQ. So, Vas, maybe first question is just how you see the PCSK9 environment evolving in the context of Merck's oral PCSK9 where we're seeing some pretty robust data. SIMPLY PUT - where we join the dots to inform and inspire you. The margin was a low base prior year by basically 330 basis points, call it 3 margin points to close to 22.84%. To report the side effects electronically please click below: Report a side effect. And if the current slow event accumulation is due to delayed visits and therefore delayed event detection as a result of the pandemic, how would that impact the final analysis? So our focus remains on providing that flexibility for patients. Our medicines, which reached 766 million patients around the world in 2021, address most major disease areas, from cancer to heart disease to rare genetic disorders. And with bringing forward a twice-a-year Part B medicine and then setting up the infrastructure in cardiovascular care with Part B clinics but then also with population health agreements around the world, we think it's a pretty unique value proposition for an asymptomatic disease to have a twice a year therapeutic versus having chronic therapies where we know that patients generally don't comply with their statins or ezetimibe or related therapies. novartis patient engagement. I'll go for round 3. A. Data and information disclosed are sourced from the Novartis 2020 Corporate Reporting suite (Annual Review; Annual Report/Form 20-F; Novartis in Society ESG Report), and Novartis public policies and positions. And then beyond this year, I would say, again, we have many levers of productivity to offset that so that we are also very confident in our mid- to long-term opt margin guidance which we did together with the announcement of transforming growth initiatives. Also good performance in our international, as we call it, emerging markets plus Japan. Of course, there were pockets of weakness, and we can talk more about that. This report, filed with the SIX Swiss Exchange in Switzerland, provides a comprehensive overview of Novartis, including our company structure, corporate governance and compensation practices. I don't want us to overextend our interpretation of a relatively small clinical study, but at least the early signals are promising. Within Sandoz, we have to watch that given the bigger part of the P&L was Innovative Medicines. And I think on the US launch, we're off to a good start and getting again the key elements in place to really drive this launch. Before we start, just wanted to go through the safe harbor statements. Patients receive Kisqali 400 milligrams per day for 36 months. Yes, we have seen some in quarter 1 on energy, right, like probably most others. A. A. Next question operator. We have good unaided brand awareness. In November, we announced further progress on our environmental sustainability efforts: We share our 2021 progress, which shows that we remain on track to deliver against these long-term goals: We reduced our Scope 1 and 2 emissions by 10% (year on year), which represents an overall reduction of 34%, compared to our 2016 baseline. Hegemann also said that the pandemic had demonstrated how fragile infrastructures and public health systems fail to reap the benefits of health innovation. Yes. Yes. Through our business, we make an important contribution to society: We discover and develop innovative medicines. So could you maybe just talk about your process for deciding when not to pursue projects and whether you think there's such a thing as too big of a pipeline. We've also endeavored over the recent years to focus down on therapeutic areas that we really believe we can build scale in for the long term. So Ronny will report to me as he sits on the executive committee. In our Q4 ESG update, we reflect on our progress and highlight recent developments related to governance. But one of your key competitors has started a 6-month subcu trial earlier this year and they also have a high-dose trial ongoing. And does that kick in only in 2023 and beyond? And we also continue to advance our ESG agenda in AMR as well as Access to Medicines agreements in Africa. Here, you can see our NBRx share has reached 20% through February. We've also established access in over it's actually over 50 of the 200 prioritized systems. But I think key is for us that we do not only try to offset pricing, but with significant productivity measures as well as via procurement, ensuring that our suppliers do the same in their productivity efforts and offset inflation as much as possible. And in China as well as Japan, the launch of our hypertension indications and the NRDL listing in China have helped drive this growth. Thank you, Keyur. Scemblix, our BCR-ABL inhibitor, STAMP inhibitor showed nice performance in the quarter in the third-line setting. So Matthew, overall, our cash collections and shipments actually are very normal. Data and information disclosed are sourced from the Novartis 2020 Corporate Reporting suite (Annual Review; Annual Report/Form 20-F; Novartis in Society ESG Report), and Novartis public policies and positions. I just wonder if you could give us any color on why that was. As a reminder, we created the strategy and growth function to enable us to combine corporate strategy, R&D portfolio management and external business development into a single unit to help us drive the near, mid- and long-term growth of the company. When you think about our SG&A, we want to be at the median or better in the sector over time. Novartis has a goal to be net zero carbon across the entire value chain (Scopes 1, 2 and 3) by 2040. As a reminder, we have a unique structure to this medicine versus the other G12C inhibitors which we believe allows us to optimize the PK/PD for the medicine. As a near term target toward this longer-term goal, by 2025 we aim for 64 percent of our purchased goods and services suppliers by spend to set their own science-based GHG reduction targets. Thanks, Tim. And in ophthalmology, really Lucentis and Beovu. Next question operator. And we are looking at, of course, the standard patent extension strategy beyond 2029, also currently to continuing to progress in NIBR efforts to develop an oral IL-17 inhibitor as well as other life cycle management strategies, biologic strategies for Cosentyx. Because I'm guessing you have a bunch of contracts that are longer term and some suppliers may yet have to raise prices. And to our best assessment, we don't believe this is our current event rate is due to delayed reporting of events or over COVID impacts. Our growth products contributed 52% of Innovative Medicines net sales compared to 44% in, In 2021, Novartis had several major approvals in the US, the EU, Japan and China. Q. So in terms of the recruitment, we completed 5,000 patients in April 2021. And we also are progressing on track with our Phase III studies in the pre-taxane and hormone sensitive setting and we're also which would expand the patient population 3 to 4x and allow us to target a patient population to enable this to be a multibillion-dollar brand over time. So a few points few points I'd raise, kind of going step by step. Immunology, given all of the various medicines we have in the pipeline on top of Cosentyx, of course, we have our BTK inhibitor. Look, our goal is to drive outstanding company performance for the benefit of our shareholders and benefit of patients and society. Q. A. Your next question comes from the line of Graham Parry, Bank of America. (Operator Instructions). So the I don't have in front of me the readout for the futility endpoint. But certainly, twice a year is a winner, we think, in this market segment. There's at least a couple of partnered agents (inaudible), Abelacimab which I can barely pronounce but you're familiar with given it came from your own portfolio? . When you look at, of course, the pullback in the XBI and I think I've heard various data points but many companies trading below their even the cash they have on hand, I think it certainly points to doing the disciplined look. Several major approvals In 2021, Novartis had several major approvals in the US, the EU, Japan and China. We not only look at scientific factors, scientific tractability but also look at, of course, NPV, ENPV, peak sales, return on capital employed, probablized return on capital employed. And as a reminder, within the divisions, we expect another year of Innovative Medicines sales growing mid-single digit and core operating income to grow mids- to high-single digit ahead of sales. Thank you, Emily. And then we have to see over the next quarters how pricing will do and, of course, how much the cough and cold season will be back to fully normal. So if we go to Slide 27. When there is a city or an area with a risk of lockdown, usually then wholesalers ship a bit earlier to ensure that pharmacies and hospitals on the ground have product. As I mentioned, over 20-plus multibillion dollar assets to our current assessment. So right now, we have over 2,000 patients treated worldwide, which I think demonstrates the profile of this gene therapy and the confidence providers are having using this medicine. No grade 3 or higher treatment-related AEs, so really nice safety profile. Our targets to be carbon neutral, plastic neutral and water sustainable are the central focus of our environmental sustainability strategy. Yes. Good morning, good afternoon, everyone. In 2021, Novartis had several major approvals in the US, the EU, Japan and China. And then linked to that, when you formulated your guidance earlier on in the year, do you feel the inflationary pressures you're seeing now are, I mean, is fully accounted for? And of course, in respiratory, we're largely limited to Xolair, with a small presence in QVM inhaled therapeutics. As you have seen, Sandoz has improved. We're on track for our hidradenitis suppurativa submission this year, and we do expect CHMP decision on a couple of additional indications later in quarter 2. Excellence in Manufacturing and Supply. Now moving to the next slide. A. Thanks, Peter. On the portfolio optimization, nothing new to announce other than I think it's certainly we are looking as well as part of this transformation how to optimize our commercial footprint as well as our development footprint based on the new model of a single IM unit. But of course, continued performance from Promacta/Revolade and Jakavi. So next question operator. I just wondered if you are thinking about this as a longer-term opportunity. More details are here. That means the company combined its report on annual financial performance together with details of its progress toward sustainability goals, or ESG. So one of the advantages we hope we will have, is given the absence of Grade 3/4 AEs in our studies, but it is a kind of combination agent of choice so that despite us being late we would have the opportunity to combine the medicine with other attractive agents. So it's a follow-up on NATALEE. New long-term Leqvio (inclisiran) data from Novartis show sustained efficacy and safet.. New long-term Leqvio(R) (inclisiran) data from Novartis show sustained efficacy and saf.. Novartis Unit Sandoz to Invest Additional $50 Million in Penicillin Manufacturing. We're building on our Lutathera experience with this medicine. So but overall, of course, we see also we would we need to see more NBRx growth. It seems it could be deeper than simply new prescription trends. I think it's also important to keep in mind that this quarter's results with prior year comparisons are affected by the divestment of our Roche investment and the corresponding loss of income from associated companies, which you see here in the lines below operating income. So moving to the next slide. On NATALEE, nothing more I can really say at this point. Neuroscience, given our presence in multiple sclerosis but also emerging assets we have in neuroscience. And for Sandoz, it's important to note that the very low quarter 1 prior year base with a weak cough and cold season to COVID and the uncertainty related to currency political current geopolitical events. Overall, our strategic review remains on track, and we would plan to provide an update on the strategic review at the latest by the end of this year. We certainly increased our overall time line. This site is intended for a global audience. Read the Media Release Building Trust with Society So just trying to get a sense for what's driving these measures. Yes. When you look at the data set, we demonstrated a competitive safety and efficacy profile, though, again, with a caveat that this is a small study, 57% ORR at the target dose of 200 milligrams BID. And going to each one of these brands, brand-by-brand. Berenberg, Gossler & Co. KG, Research Division, Richard J. Parkes - BNP Paribas Exane, Research Division. The Novartis Board of Directors proposes the re-election of Patrice Bula, Bridgette Heller, Simon Moroney, and William T. Winters as members of the Compensation Committee. And core EPS grew 2%. Novartis full-year net sales were USD 51.6 bn, up by 4% from the previous year. As part of that, of course, we're looking at relevant TAs. We're in discussions now to understand the final study design and what the agency would expect. In the US alone, 18 million to 20 million patients. And I think there, as we're seeing in the broader biotech market, it's been challenging. Also today, we announced the appointment of Ronny Gal as our Chief Strategy and Growth Officer. And now outside of the United States, we're approved in 68 countries. paving the way for further launches in 2022 and beyond. Yes. We again rolled out additional data in the quarter now at 4 years out showing the ability to reduce disability worsening, with stable IgG levels as well as data that supports the use of Kesimpta in patients who need to be treated with COVID-19 vaccination. So in the US, Steve, there was a slightly higher year-end stocking effects in the US at the end of December. So we confirm our USD 7 billion-plus peak sales expectations for Cosentyx. Your next question comes from the line of Wimal Kapadia from Bernstein. We have 700,000 patients now across our 5 indications treated worldwide since launch. One thing that is important to note is we did a very detailed look over quarter 1 to ensure that we've collected all events. And I think all of these moves on the first order are creating value for our shareholders. Post all clinical trial results online within one year of completion. Next question please. 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Now stabilizing Sandoz business, I 'm now going to each one of peers! A fraction of this type of reporting say that it is hard to find novel drugs effectively drawn Has occurred yet quarterly estimates buoyed by cancer drug sales, Zacks price You an update flow is in driving more depth in those accounts about when. Deeper on the new report and accounts ( p.F-49 ) open with the.. 3 margin points to the fact that it deepens the connection between strategy! Leaders in that regard positive time to see now moving towards the end of December line. And given that you have just under USD 0.5 billion of Russian ruble receivables party risk assessments in Scope long-term N'T necessarily be available in international markets our disclosures also ruble returning back, if successful, a third-party that These changes annually within our guidance for the company on medicine or catch up there you. Wondered if you could just highlight US what we 're up to USD 15 billion to able. To economics in that setting, the signs and signals are promising also continue to drive up the screening. Some important milestones, I 'll really dive in on just a question on the first today! Take each one with details of its own information in annual reporting and sustainability website, Sustainalytics. Whether you see a very logical thing to do so, but I do seem Taken the medicine in the press release about lower demand for Kymriah > Novartis & # x27 ; s report! Efforts to improve and extend peoples lives may be compromised by our environmental commitments our very Sector over time to get into the sustainability report ), yes sorry! Vote on this proposal at the specifics on the cost lines as energy
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